This paper researches connection between shift work and special working conditions with satisfaction and health of an employees and their intentions of change of workplace. Nowadays shift work is more common, especially in industries and production lines since they can't afford to stop the production of goods. It has negative impact on a lot of aspects of human life and those will be grouped them in four general categories: biological functions, working efficiency, family and social life and health. Special working conditions are those that can be performed only by individuals who meet certain special requirements in aspects of age, sex, professional and psychic abilities and health condition. Only they can work on those positions because of possibility of recurring adverse health effects. For the purpose of writing this paper empirical research has been conducted on a sample of 65 employees of one factory, and all of them are working in shifts and most of them are working under special working conditions in the company for more than 10 years. The perception of the consequences of such work on their psycho-physical condition, i.e. on health, satisfaction with work and quality of life, and on the intentions of job change, has been examined. The results show that shift work has extent negatively effects on the life of an individual, and causes more negative consequences than work in special conditions. While work in special conditions only harms health, shift work also affects various aspects of life. Most respondents are moderately satisfied with the working conditions (M = 2.87). They say they were thinking about job change. Although they generally understand that working conditions cannot be significantly improved due to the nature of the manufacturing process, they feel they would be more satisfied if their work and occupational health were more valued and better paid.