In order to ensure the improvement of entrepreneurial activity in certain regions, it is necessary that local community provides adequate conditions and incentives for the development of entrepreneurship. This among other things means the existence of entrepreneurial support institutions which will provide necessary information on the business and the market and also information about the incentives that can be used for entrepreneurs. This paper analyzes the entrepreneurship of the municipality of Orebić to determine the current level of development as well as the plans for its future development. Methods that were used while writing this paper are quantitative and qualitative methods. Qualitative research was conducted using secondary data sources, i.e. books, professional articles, and Internet data sources that are related to the topic being dealt with. Qualitative information refers to primary sources of data and is collected through conducting survey research with entrepreneurs from Orebić municipality, while quantitative information relate to secondary sources of data, i.e. books, professional articles and Internet sources related to the topic of this paper. Through conducting the research, it was established that there is a need to improve the entrepreneurial activity and infrastructure of the municipality of Orebić, which can be achieved through the launch of entrepreneurial support institutions in the area. This will ensure a favorable environment for the development of entrepreneurial activity. Also some of the ways to improve entrepreneurship in the mentioned area include the organization of additional education for entrepreneurs, better financing of entrepreneurial activities, better promotion of the municipality etc. Promoting entrepreneurship will also ensure the local development of the municipality, which will also contribute to the overall economic development of Croatia.