During 2020, Croatia faced not only the COVID-19 pandemic but also two powerful earthquakes. The first occurred in March in the City of Zagreb and Zagreb County, while the second struck on December 29 of the same year, impacting the Sisak-Moslavina County. The material damage was immense, with many buildings destroyed or damaged, and there were seven human casualties. The earthquake caused significant material damage in the cities of Sisak, Petrinja, Glina, and surrounding settlements. The estimated cost of damage in Sisak-Moslavina County exceeded 5 billion euros. This amount includes the material assets of local entrepreneurs whose businesses were severely disrupted by the earthquake's consequences. The purpose of this study is to examine the effects of the earthquake on the businesses of entrepreneurs and craftsmen in the Sisak-Moslavina County using a survey questionnaire method. The research highlights the ways in which the earthquake impacted entrepreneurs and craftsmen in Sisak-Moslavina County, the problems and challenges they faced at the time, and the consequences of the earthquake, as well as the response of various stakeholders on the business activities of local entrepreneurs today, four years after the earthquake. The research results highlight the need for greater institutional support, faster recovery processes, and long term strategic investments to ensure economic stability. It is recommended to enhance investments in local entrepreneurship, modernize infrastructure, and foster coordinated collaboration among key stakeholders at the national and regional levels.