The aim of this paper is to present the elements of a marketing plan for package tours intended for people with Down syndrome and their assistants. Through the conducted primary research, it seems that there is currently no specialized tourist agency in Croatia that offers a package tour for people with Down syndrome, or that it is not advertised via the Internet. The specificity of areas of interest, desires and needs play a major role in creating a package tour, and certain limitations regarding the basic elements (transportation, accommodation, movement, etc) further increase the complexity of the task. For this purpose, a simpler reconnaissance survey was conducted in which the attitudes of a limited number of family members of people with Down syndrome were collected and analyzed. For the travel agency that is the subject of this paper, the positioning and competitive strategy are described, and then the basic elements for the creation of a marketing strategy are discussed in detail. Also, elements were presented in terms of product and price of one package tour intended for parents under the age of 50 and one person with Down syndrome for 17 years through the marketing mix. The package tour designed for the purpose of this work provided for the organization of a return trip from Zagreb to Makarska and 6 nights at the Hotel Biokovka. Through the conducted research, competition analysis and other considerations, an attempt was made to determine the justification of starting a business venture oriented to a narrow market niche of people with Down syndrome and their companions.